Mendelian randomization explored causal associations between immune diseases and artificial joint reoperation

doi:10.3877/ cma.j.issn.1674-134X.2025.02.009

Abstract

Abstract:

Objective

To explore the causal association between immune diseases and artificial joint reoperation using Mendelian randomization analysis.

Methods

Through screening public data from nonoverlapping genome-wide association studies, the exposure factors were inflammatory bowel disease, psoriasis,rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, and the outcome factors were resurgery for artificial joints. inverse variance weighted (IVW) method was adopted as the main analysis method to evaluate the causal effect in this study. The Mendel randomization-Egger method (MR-Egger), weighted median method, weighted mode model and simple mode were used as supplementary methods, and the sensitivity analysis was carried out.

Results

IVW estimates suggested that psoriasis is a risk factor for reoperation of artificial joints［OR=1.12，95%CI (1.01，1.25), P=0.026］. There was no statistically significant occurrence of inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis, systemic lupus erythematosus, or artificial joint reoperation in this study (all P>0.05).

Conclusion

There is a causal association between psoriasis and artificial joint reoperation that may increase the risk of artificial joint reoperation.

Key words: Mendelian randomization analysis, Immune system diseases, Arthroplasty,replacement

Yanji Shi, Lei Zhang, Ningbo Lei, Ruilong Chang, Ning Zuo, Yubiao Gu. Mendelian randomization explored causal associations between immune diseases and artificial joint reoperation[J]. Chinese Journal of Joint Surgery(Electronic Edition), 2025, 19(02): 193-199.

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Figures/Tables 2

References 42

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暴露因素Exposure factors	结局Outcomes	SNP个数SNP number	方法Methods	OR（95%CI）	效应P值Effect P value	异质性P值Heterogeneit P value	截距项P值Intercept P value
			IVW	1. 05（0. 96，1. 14）	0. 293	0. 522	-
			MR-Egger	1. 11（0. 96，1. 27）	0. 169	0. 519	0. 345
炎症性肠病Inflammatory bowel disease	人工关节再手术	95	加权中位数法	1. 11（0. 97，1. 28）	0. 134	-	-
			简单模型	0. 81（0. 59，1. 12）	0. 204	-	-
			加权模型	1. 09（0. 95，1. 26）	0. 202	-	-
			IVW	1. 12（1. 01，1. 25）	0. 026	0. 490	-
			MR-Egger	1. 12（0. 97，1. 30）	0. 152	0. 401	0. 972
银屑病Psoriasis	人工关节再手术	12	加权中位数法	1. 14（1. 00，1. 29）	0. 051	-	-
			简单模型	1. 11（0. 89，1. 38）	0. 392	-	-
			加权模型	1. 13（1. 00，1. 28）	0. 068	-	-
			IVW	1. 05（0. 97，1. 15）	0. 222	0. 075	-
			MR-Egger	1. 09（0. 96，1. 25）	0. 179	0. 071	0. 465
类风湿性关节炎Rheumatoid arthritis	人工关节再手术	82	加权中位数法	1. 12（1. 00，1. 26）	0. 043	-	-
			简单模型	0. 88（0. 69，1. 12）	0. 309	-	-
			加权模型	1. 11（1. 01，1. 22）	0. 031	-	-
			IVW	0. 99（0. 89，1. 09）	0. 804	0. 732	-
			MR-Egger	0. 94（0. 78，1. 13）	0. 489	0. 713	0. 506
多发性硬化Multiple sclerosis	人工关节再手术	44	加权中位数法	1. 01（0. 85，1. 19）	0. 918	-	-
			简单模型	1. 07（0. 79，1. 45）	0. 652	-	-
			加权模型	1. 02（0. 86，1. 21）	0. 850	-	-
			IVW	1. 10（0. 96，1. 26）	0. 162	0. 915
			MR-Egger	1. 19（0. 71，2. 00）	0. 553	0. 834	0. 775
系统性红斑狼疮Systemic lupus erythematosus	人工关节再手术	5	加权中位数法	1. 09（0. 93，1. 28）	0. 284	-	-
			简单模型	1. 11（0. 90，1. 37）	0. 385	-	-
			加权模型	1. 09（0. 91，1. 30）	0. 410	-	-

暴露因素Exposure factors	结局Outcomes	SNP个数SNP number	方法Methods	OR（95%CI）	效应P值Effect P value	异质性P值Heterogeneit P value	截距项P值Intercept P value
			IVW	1. 05（0. 96，1. 14）	0. 293	0. 522	-
			MR-Egger	1. 11（0. 96，1. 27）	0. 169	0. 519	0. 345
炎症性肠病Inflammatory bowel disease	人工关节再手术	95	加权中位数法	1. 11（0. 97，1. 28）	0. 134	-	-
			简单模型	0. 81（0. 59，1. 12）	0. 204	-	-
			加权模型	1. 09（0. 95，1. 26）	0. 202	-	-
			IVW	1. 12（1. 01，1. 25）	0. 026	0. 490	-
			MR-Egger	1. 12（0. 97，1. 30）	0. 152	0. 401	0. 972
银屑病Psoriasis	人工关节再手术	12	加权中位数法	1. 14（1. 00，1. 29）	0. 051	-	-
			简单模型	1. 11（0. 89，1. 38）	0. 392	-	-
			加权模型	1. 13（1. 00，1. 28）	0. 068	-	-
			IVW	1. 05（0. 97，1. 15）	0. 222	0. 075	-
			MR-Egger	1. 09（0. 96，1. 25）	0. 179	0. 071	0. 465
类风湿性关节炎Rheumatoid arthritis	人工关节再手术	82	加权中位数法	1. 12（1. 00，1. 26）	0. 043	-	-
			简单模型	0. 88（0. 69，1. 12）	0. 309	-	-
			加权模型	1. 11（1. 01，1. 22）	0. 031	-	-
			IVW	0. 99（0. 89，1. 09）	0. 804	0. 732	-
			MR-Egger	0. 94（0. 78，1. 13）	0. 489	0. 713	0. 506
多发性硬化Multiple sclerosis	人工关节再手术	44	加权中位数法	1. 01（0. 85，1. 19）	0. 918	-	-
			简单模型	1. 07（0. 79，1. 45）	0. 652	-	-
			加权模型	1. 02（0. 86，1. 21）	0. 850	-	-
			IVW	1. 10（0. 96，1. 26）	0. 162	0. 915
			MR-Egger	1. 19（0. 71，2. 00）	0. 553	0. 834	0. 775
系统性红斑狼疮Systemic lupus erythematosus	人工关节再手术	5	加权中位数法	1. 09（0. 93，1. 28）	0. 284	-	-
			简单模型	1. 11（0. 90，1. 37）	0. 385	-	-
			加权模型	1. 09（0. 91，1. 30）	0. 410	-	-

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